Gallbladder and bile duct cancers are the growth of abnormal cells in the gallbladder and/or the tubes that connect the gallbladder to the liver and intestines. These abnormal cells ultimately grow and produce a tumor, which can cause pain and/or the inability to drain bile. The chemical in bile called bilirubin backs up into the bloodstream and produces a characteristic yellow skin and eye coloring called jaundice. These cancers are rare. People with a higher risk of developing one of these cancers include those with liver fluke infections, sclerosing cholangitis, ulcerative colitis and cirrhosis.