IndicationsOxycodone is used to relieve moderate to severe pain. Oxycodone extended-release tablets are only used to treat people who are expected to need medication to relieve moderate to severe pain around the clock. Oxycodone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Oxycodone is also available in combination with acetaminophen (Endocet, Percocet, Roxicet, Tylox, others); aspirin (Endodan, Percodan, Roxiprin, others); and ibuprofen (Combunox). This monograph only includes information about the use of oxycodone alone. If you are taking an oxycodone combination product, be sure to read information about all the ingredients in the product you are taking and ask your doctor or pharmacist for more information.
DoseringOxycodone comes as a solution (liquid), concentrated solution, tablet, capsule, and extended-release (long-acting) tablet to take by mouth. The solution, concentrated solution, tablet, and capsule are usually taken with or without food every 4 to 6 hours, either as needed for pain or as regularly scheduled medications. The extended-release tablets are taken every 12 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take oxycodone exactly as directed. If you are taking the oxycodone concentrated solution, be sure to carefully measure and double check the dose before taking the medication. Use the measuring dropper that comes with the medication to measure your dose. Mix the medication with at least 1 ounce (30 milliliters) of juice or other liquid, or with a semi-solid food such as applesauce or pudding. If you are taking oxycodone concentrated solution from an ampule (small pre-packaged tube containing oxycodone liquid), be sure to follow your doctor's instructions for taking a dose. Ask your pharmacist or doctor if you have any questions about measuring your dose or taking your medication. If you are taking the extended-release tablets, swallow the tablets one at a time with plenty of water. Swallow the tablet right after putting it in your mouth. Do not presoak, wet, or lick the tablets before you put them in your mouth. Your doctor will likely start you on a low dose of oxycodone and may increase this dose over time if your pain is not controlled. After you take oxycodone for a period of time, your body may become used to the medication. If this happens, your doctor may need to increase your dose to control your pain. Talk to your doctor about how you are feeling during your treatment with oxycodone. Do not stop taking oxycodone without talking to your doctor. If you stop taking this medication suddenly, you may experience withdrawal symptoms such as restlessness, watery eyes, runny nose, sneezing, yawning, sweating, chills, muscle or joint aches or pains, weakness, irritability, anxiety, depression, difficulty falling asleep or staying asleep, cramps, nausea, vomiting, diarrhea, loss of appetite, fast heartbeat, and fast breathing. Your doctor will probably decrease your dose gradually. Ask your doctor or pharmacist for a copy of the manufacturer's information for the patient.
VoorzichtigBefore taking oxycodone, tell your doctor and pharmacist if you are allergic to oxycodone, any other medications, or any of the ingredients in oxycodone liquid, tablets, extended-release tablets, or capsules. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants;certain antibiotics including clarithromycin (Biaxin, in Prevpac) and erythromycin (E.E.S., Ery-C); certain antifungal medications including itraconazole (Sporanox) and ketoconazole (Nizoral); antihistamines (found in cold and allergy medications); diuretics ('water pills'); buprenorphine (Buprenex, Subutex, in Suboxone); butorphanol (Stadol); carbamazepine (Carbatrol, Equetro, Tegretol); certain medications for human immunodeficiency virus (HIV) including indinavir (Crixivan), nelfinavir (Viracept) and ritonavir (Norvir, in Kaletra); ipratropium (Atrovent); medications for glaucoma, irritable bowel disease, Parkinson's disease, ulcers, and urinary problems;nalbuphine (Nubain); naloxone (Narcan); phenobarbital; phenytoin (Dilantin); pentazocine (Talwin); rifabutin (Mycobutin) and rifampin (Rifadin, in Rifamate, in Rifater). Also tell your doctor or pharmacist if you are taking the following medications or if you have stopped taking them within the past two weeks: isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section, a blockage in your stomach or intestines, or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to take oxycodone. Also tell your doctor if you have or have ever had a head injury,a tumor in your brain or nervous system, any condition causing increased pressure in your brain; hypothyroidism (condition in which the thyroid gland produces less hormone than normal), low blood pressure;Addison's disease (condition in which the adrenal gland does not produce enough hormone), seizures; urethral stricture (blockage of the tube that allows urine to leave the body), enlarged prostate (a male reproductive gland), or heart, kidney,liver, or pancreas, or biliary tract disease. If you will be taking the extended-release tablets, also tell your doctor if you have or have ever had diverticulitis (condition in which small pouches form in the intestines and become swollen and infected), colon cancer (cancer that begins in the large intestine) or esophageal cancer (cancer that begins in the tube that connects the mouth and stomach). if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking oxycodone. you should know that this medication may make you drowsy. Do not drive a car, operate heavy machinery, or participate in any other possibly dangerous activities until you know how this medication affects you. ask your doctor about the safe use of alcoholic beverages while you are taking oxycodone. When alcohol is taken with this medication, dangerous side effects can occur. you should know that oxycodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To help avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
Oxycodone may cause side effects. Tell your doctor if any of these symptoms, are severe or do not go away:
- loss of appetite
- dry mouth
- dizziness or lightheadedness
- mood changes
- narrowing of the pupil (dark circle in eye)
- red eyes
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- fast or slow heartbeat
- difficulty breathing
- slowed breathing
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- difficulty swallowing
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch
] or by phone [1-800-332-1088].Oxycodone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.