Bleeding from the nose. The most common cause is trauma from a finger or foreign body, or from drying of the nasal mucosa. Most bleeding is from the front part of the nose along the nasal septum. In this area is a collection of small arteries and veins called Kiesselbach's plexus and irritation of the nasal mucosa in this area can result in significant bleeding. Bleeding from the rear of the nose (posterior epistaxis) is more difficult to control and may require admission to the hospital.