Charcot-Marie-Tooth disease is an inherited disorder of the nerves of the arms and legs. Over time, the disease causes decreased sensation in the affected limbs and muscle loss. Symptoms usually begin in childhood or early adulthood. Foot deformities such as high arches (pes cavus) and hammer toes are common and characteristic of the disease. Over time, muscle weakness may cause clumsiness and make it difficult to walk.